treatment-responsiveness of negative symptoms in schizophrenia: a double-blind placebo-control clinical trial

نویسندگان

s. shoja-shafti

چکیده

background: the negative symptoms of schizophrenia remain a major clinical challenge. nortriptyline is a serotonin and noradrenalin reuptake inhibitor and belongs to secondary amine tricycles. the aim of this study is to evaluate the effect of nortriptyline on the negative symptoms of schizophrenia.   methods: this study is a six-week randomized placebo-control trial of nortriptyline or placebo as an adjunctive to haloperidol (5 mg) in the treatment of 50 patients with diagnostic and statistical manual for mental disorders (dsm-iv) criteria for chronic schizophrenia.   result: the primary finding of the trial was a significant reduction in scale for assessment of negative symptoms (sans) in the nortriptyline group compared to placebo at the end of 6 week. all the subscales of sans demonstrate significant improvement.   conclusion: this study suggests a potential role for nortriptyline in the treatment of negative symptoms of schizophrenia. iran j med sci 2006; 31(3): 135-138.   keywords ● schizophrenia ● negative symptom ● nortriptyline

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Treatment-Responsiveness of Negative Symptoms in Schizophrenia: A double-blind placebo-control clinical trial

Background: The negative symptoms of schizophrenia remain a major clinical challenge. Nortriptyline is a serotonin and noradrenalin reuptake inhibitor and belongs to secondary amine tricycles. The aim of this study is to evaluate the effect of nortriptyline on the negative symptoms of schizophrenia. Methods: This study is a six-week randomized placebo-control trial of nortriptyline or placebo a...

متن کامل

Effects of Bromocriptine on Negative Symptoms of Schizophrenia: A Double Blind Clinical Trial

Negative symptoms are still a major obstacle in the recovery of schizophrenic patients. Many attempts to develop novel drugs affecting negative symptoms of schizophrenia have yielded insignificant results. This study evaluates the effects of bromocriptine, a dopamine agonist, on negative symptoms of schizophrenia utilizing a placebo-controlled crossover double-blind clinical trial. Methodology:...

متن کامل

Effects of Atorvastatin on negative sign in chronic schizophrenia: A double blind clinical trial

The aim of this study was to evaluate the effects of Atorvastatin on negative symptoms in patients with chronic schizophrenia. The study was a prospective, double-blind, 6-week trial. Forty patients participated in the study; 19 patients were assigned to the Atorvastatin group as well as 21 patients to the placebo group. For assessing negative signs, we used Scale for the Assessment of Negative...

متن کامل

Effects of Atorvastatin on negative sign in chronic schizophrenia: A double blind clinical trial

The aim of this study was to evaluate the effects of Atorvastatin on negative symptoms in patients with chronic schizophrenia. The study was a prospective, double-blind, 6-week trial. Forty patients participated in the study; 19 patients were assigned to the Atorvastatin group as well as 21 patients to the placebo group. For assessing negative signs, we used Scale for the Assessment of Negative...

متن کامل

The effect of Ascorbic Acid as supplementary treatment with risperidone in controlling the symptoms of schizophrenia: A double-blind, placebo-controlled clinical trial

Background and Objective: Considering the hypothesis of the effects of the use of antioxidants such as ascorbic acid on the improvement of oxidative stress induced by schizophrenia, the present study was designed to investigate the effect of ascorbic acid as an adjunctive therapy with risperidone in controlling the symptoms of schizophrenia. Materials and Methods: This randomized clinical tria...

متن کامل

Methoxsalen bath in the treatment of palmoplantar Eczema: A double-blind, placebo controlled clinical trial

Background: Palmoplantar eczema is a common clinical problem involving 2% of the population. There are many treatment modalities for palmoplantar eczema, each with specific local and systemic side effects. Objective: To evaluate methoxsalen bath in the treatment of palmoplantar eczema. Patients and Methods: In a randomized, double-blind, placebo controlled clinical trial, 60 patients with palmo...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of medical sciences

جلد ۳۱، شماره ۳، صفحات ۰-۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023